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 – Final Community herbal monograph on Vitex agnus-castus L., fructus. London: EMA. Doc. Ref.: EMA/HMPC/606742/2017. Adopted: 10-10-2018.

– Assessment report on Vitex agnus-castus L., fructus. London: EMA. Doc. Ref.: EMA/HMPC/606741/2018. Adopted: 10-10-2018.

– Final list of references supporting the assessment of Vitex agnus-castus L., fructus. London: EMA. Doc. Ref.: EMA/HMPC/795807/2017. Adopted: 10-10-2018.

– Verkaik S, Kamperman AM, van Westrhenen R, Schulte PFJ. The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;217(2):150-166. doi:10.1016/j.ajog.2017.02.028

– A. R. Carmichael, "Can Vitex Agnus castus Be Used for the Treatment of Mastalgia? What Is the Current Evidence?", Evidence-Based Complementary and Alternative Medicine, vol. 5, Article ID 651379, 4 pages, 2008. https://doi.org/10.1093/ecam/nem074

Ayuda a aliviar la intensidad del dolor de las mamas (mastalgia) debido a cambios hormonales y ayuda a aliviar estados de hiperprolactinemia (elevación de prolactina) que ocurren durante el periodo premenstrual.

Despite some methodological limitations, the results from randomised, controlled trials to date suggest benefits for Vitex extracts in the treatment of premenstrual syndrome, premenstrual dysphoric disorder and latent hyperprolactinaemia. (Referencia: van Die, M. Diana, Henry G. Burger, Helena J. Teede, and Kerry M. Bone.

– Cerqueira RO, Frey BN, Leclerc E, Brietzke E. Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Arch Womens Ment Health. 2017;20(6):713-719. doi:10.1007/s00737-017-0791-0

El extracto de Vitex A.C. es una alternativa segura y eficaz a considerar para el tratamiento de los síntomas de SPM y el SDPM.

Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia:A Systematic Review and Meta-Analysis

Soo Liang Ooi, BHSc (Comp Med), MMath,1,2Stephanie Watts, BHSc (Comp Med),2Rhett McClean, PhD,2and Sok Cheon Pak, PhD2  

Dolor menstrual

Is there a role for Western herbal medicine in treating cyclic perimenstrual pain and discomfort?Carole Y. Fisher, Jon Adams, Jane E. Frawley, Louise D. Hickman and David W. Sibbritt

- Aksoy AN, Gözükara I, Kabil Kucur S. Evaluation of the efficacy of Fructus agni casti in women with severe primary dysmenorrhea: a prospective comparative Doppler study. J Obstet Gynaecol Res. 2014;40(3):779-784. doi:10.1111/jog.12221

Comparative evaluation of the efficacy of herbal drugs (fennelin and vitagnus) and mefenamic acid in the treatment of primary dysmenorrhea

Fatemeh Zeraati,1 Fatemeh Shobeiri,2 Mansour Nazari,3 Malihe Araghchian,1 and Reza Bekhradi4


Hum Psychopharmacol. 2003 Apr;18(3):191-5.

- Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003;18(3):191-195. doi:10.1002/hup.470

- Rafieian-Kopaei M, Movahedi M. Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus. Electron Physician. 2017;9(1):3685-3689. Published 2017 Jan 25. doi:10.19082/3685

The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis

Sanaz Mollazadeh

/ Mojgan Mirghafourvand

/ Nafiseh Ghassab Abdollahi

Published Online: 2019-07-31 | DOI: https://doi.org/10.1515/jcim-2018-0053

Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials

 Arch Womens Ment Health. 2017 Dec;20(6):713-719. doi: 10.1007/s00737-017-0791-0.

Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia:A Systematic Review and Meta-Analysis Soo Liang Ooi, BHSc (Comp Med), MMath,1,2Stephanie Watts, BHSc (Comp Med),2Rhett McClean, PhD,2and Sok Cheon Pak, PhD

- Naseri R, Farnia V, Yazdchi K, Alikhani M, Basanj B, Salemi S. Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study. Korean J Fam Med. 2019;40(6):362-367. doi:10.4082/kjfm.18.0067

Epub 2017 Oct 23.Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.Cerqueira RO(1), Frey BN(2)(3), Leclerc E(1), Brietzke E(4)).


EDX List of Potential Endocrine Disruptors

RISCTOX: Disruptores endocrinos

Comisión Europea: Lista prioritaria de disruptores endocrinos

Haya, Risco & Rodríguez, 2005

Navarro, Mª Concepción; Beltrán, Estanislao, 2007.

- Arentz S, Abbott JA, Smith CA, Bensoussan A. Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complement Altern Med. 2014;14:511. Published 2014 Dec 18. doi:10.1186/1472-6882-14-511

- Šošić-Jurjević B, Ajdžanović V, Filipović B, et al. Functional morphology of pituitary -thyroid and -adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil. Acta Histochem. 2016;118(7):736-745. doi:10.1016/j.acthis.2016.07.007

- Ahangarpour A, Oroojan AA, Khorsandi L, Najimi SA. Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model. Res Pharm Sci. 2017;12(2):137-143. doi:10.4103/1735-5362.202452

Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: involvement of monoaminergic systems.

Ishola IO, Ochieng CO, Olayemi SO, Jimoh MO, Lawal SM.

DOI: 10.1016/j.pbb.2014.11.005

-Roemheld-Hamm B

- Lauritzen C, Reuter HD, Repges R, Böhnert KJ, Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxine. Phytomedicine. 1997;4(3):183-189. doi:10.1016/S0944-7113(97)80066-9

- Cappelli V, Morgante G, Di Sabatino A, Massaro MG, De Leo V. Valutazione dell'efficacia di un nuovo preparato nutraceutico nel trattamento dei disturbi delle donne in postmenopausal [Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms]. Minerva Ginecol. 2015;67(6):515-521. https://pubmed.ncbi.nlm.nih.gov/26788874/

- Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci. 2013;2(3):245-254. Published 2013 Aug 31. doi:10.5681/jcs.2013.030

- Eftekhari MH, Rostami ZH, Emami MJ, Tabatabaee HR. Effects of "vitex agnus castus" extract and magnesium supplementation, alone and in combination, on osteogenic and angiogenic factors and fracture healing in women with long bone fracture. J Res Med Sci. 2014;19(1):1-7. PMC3963316

- Ambrosini A, Di Lorenzo C, Coppola G, Pierelli F. Use of Vitex agnus-castus in migrainous women with premenstrual syndrome: an open-label clinical observation. Acta Neurol Belg. 2013;113(1):25-29. doi:10.1007/s13760-012-0111-4

- Lee H, Jung KH, Lee H, Park S, Choi W, Bae H. Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model. Int Immunopharmacol. 2015;28(2):1097-1101. doi:10.1016/j.intimp.2015.07.041

- Song XL, Zhang YJ, Wang XF, et al. Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells. Cancer Cell Int. 2017;17:9. Published 2017 Jan 5. doi:10.1186/s12935-016-0377-3

 - Rosa SI, Rios-Santos F, Balogun SO, Martins DT. Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. Phytomedicine. 2016;23(1):9-17. doi:10.1016/j.phymed.2015.11.003

Activación del receptor opiáceo µ por el extracto metanólico del sauzgatillo

Ester Risco

- Webster DE, Lu J, Chen SN, Farnsworth NR, Wang ZJ. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J Ethnopharmacol. 2006;106(2):216-221. doi:10.1016/j.jep.2005.12.025

- Milewicz A, Gejdel E, Sworen H, et al. Vitex agnus castus-Extrakt zur Behandlung von Regeltempoanomalien infolge latenter Hyperprolaktinämie. Ergebnisse einer randomisierten Plazebo-kontrollierten Doppelblindstudie [Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study]. Arzneimittelforschung. 1993;43(7):752-756. https://pubmed.ncbi.nlm.nih.gov/8369008/


Joseph E. Pizzorno ND, Michael T. Murray ND, Herb Joiner-Bey ND


Link del CDC (Centro para el control y la prevención de enfermedades) : La salud reproductiva de las mujeres en el lugar de trabajo


 Patologías producidas por los desequilibrios hormonales:


Algunos datos:

Sistema endocrino

“Menstrual blood concentrations of parabens and benzophenones and related factors in a sample of Spanish women: An exploratory study”: https://www.sciencedirect.com/science/article/pii/S0013935120301201

Páginas web / Instituciones

Libros / Revistas

– Hablemos de vaginas. Salud Femenina desde una perspectiva global. Miriam Al Adib Mendiri. Ed. Oberon.

– Gansos Salvajes, revista. www.gansossalvajes.com

MyS Mujeres y Salud. Revista de Comunicación Interactiva.

– Manual introductorio a la Ginecología Natural, Pabla Pérez San Martín.

– Cuerpo Mente. Extra Salud. Plantas que curan


– Vitex, the Women´s Herb. Christopher Hobbs, L.Ac. BPC Healthy Living Publications


 – Cuerpo de Mujer, Sabiduría de Mujer: Una guia para la salud física y emocional. Christiane Northrup. Ed. Urano

 – Vicente, Macías, de la Fuente, González, Montero & Catalá-López, 2013.

– Regla sin dolor. Anna Huete, Ed. Oceano Ambar

 BOTANICAL MEDICINE FOR WOMEN’S HEALTH EBOOK. CHAPTER 5 – Menstrual Wellness and Menstrual Problems. Aviva Romm, Bevin Clare, Jill E Stansbury, Linda Ryan, Ruth Trickey, Laurel Lee, Angela J. Hywood. CHAPTER 7 -Conditions of reproductive organs. Uterine fibroids. Aviva Romm, Isla Burgess, David Winston, Suzanna M. Zick, Amanda McQuade Crawford . CHAPTER 12- Fertility Challenges Angela J. Hywood.

STENGLER, M. (2013). Los tratamientos curativos de los médicos naturistas. Ediciones Obelisco


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