– Final Community herbal monograph on Vitex agnus-castus L., fructus. London: EMA. Doc. Ref.: EMA/HMPC/606742/2017. Adopted: 10-10-2018.
Assessment report on Vitex agnus-castus L., fructus. London: EMA. Doc. Ref.: EMA/HMPC/606741/2018. Adopted: 10-10-2018.
Final list of references supporting the assessment of Vitex agnus-castus L., fructus. London: EMA. Doc. Ref.: EMA/HMPC/795807/2017. Adopted: 10-10-2018.


The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis. Verkaik S et al. Am J Obstet Gynecol. (2017)

Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Cerqueira RO et al. Arch Womens Ment Health. (2017)

Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus. Rafieian-Kopaei M et al. Electron Physician. (2017)



EDX List of Potential Endocrine Disruptors


RISCTOX: Disruptores endocrinos

Comisión Europea: Lista prioritaria de disruptores endocrinos

Haya, Risco & Rodríguez, 2005

Navarro, Mª Concepción; Beltrán, Estanislao, 2007.

Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings
Arentz S, Abbott JA, Smith CA, Bensoussan A. DOI: 10.1186/1472-6882-14-511

Acta Histochemica Functional morphology of pituitary -thyroid and -adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil.

Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: involvement of monoaminergic systems.
Ishola IO, Ochieng CO, Olayemi SO, Jimoh MO, Lawal SM.
DOI: 10.1016/j.pbb.2014.11.005

Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder.
Atmaca M, Kumru S, Tezcan E.
DOI: 10.1002/hup.470

-Roemheld-Hamm B

Phytomedicine. 1997 Sep;4(3):183-9. Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxine. 
Lauritzen C, Reuter HD, Repges R, Böhnert KJ, Schmidt U.
DOI: 10.1016/S0944-7113(97)80066-9.


Evaluation of the efficacy of Fructus agni casti in women with severe primarydysmenorrhea: a prospective comparative Doppler study. Aksoy AN, Gözükara I, Kabil Kucur S.
DOI: 10.1111/jog.12221

Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms.
Cappelli V, Morgante G, Di Sabatino A, Massaro MG, De Leo V.


Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model.
Lee H, Jung KH, Lee H, Park S, Choi W, Bae H.
DOI: 10.1016/j.intimp.2015.07.041


Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells.
Song XL, Zhang YJ, Wang XF, Zhang WJ, Wang Z, Zhang F, Zhang YJ, Lu JH, Mei JW, Hu YP, Chen L, Li HF, Ye YY, Liu YB, Gu J.


Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway.
Rosa SI, Rios-Santos F, Balogun SO, Martins DT.
DOI: 10.1016/j.phymed.2015.11.003


Joseph E. Pizzorno ND, Michael T. Murray ND, Herb Joiner-Bey ND


Páginas web / Instituciones

Libros / Revistas

– Manual introductorio a la Ginecología Natural, Pabla Pérez San Martín.

– Cuerpo Mente. Extra Salud. Plantas que curan

– Vitex, the Women´s Herb. Christopher Hobbs, L.Ac. BPC Healthy Living Publications

– Cuerpo de Mujer, Sabiduría de Mujer: Una guia para la salud física y emocional. Christiane Northrup. Ed. Urano

– Vicente, Macías, de la Fuente, González, Montero & Catalá-López, 2013.

– Regla sin dolor. Anna Huete, Ed. Oceano Ambar

BOTANICAL MEDICINE FOR WOMEN’S HEALTH EBOOK. CHAPTER 5 – Menstrual Wellness and Menstrual Problems. Aviva Romm, Bevin Clare, Jill E Stansbury, Linda Ryan, Ruth Trickey, Laurel Lee, Angela J. Hywood. CHAPTER 7 -Conditions of reproductive organs. Uterine fibroids. Aviva Romm, Isla Burgess, David Winston, Suzanna M. Zick, Amanda McQuade Crawford . CHAPTER 12- Fertility Challenges Angela J. Hywood.

STENGLER, M. (2013). Los tratamientos curativos de los médicos naturistas. Ediciones Obelisco




Mariposa Monarca Vitex

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